Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
trpml
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "trpml" in MCE Product Catalog:
10
10 Publications Verification
Target:
Forschungsgebiete:
ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral .
9
9 Cited Publications
Synonyms: ML-SI3 (cis/trans mix)
Target:
Forschungsgebiete:
ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 μM and 9.4 μM, respectively .
7
7 Cited Publications
Art. -Nr.: HY-134818
Reinheit: 99.80%
Target:
Forschungsgebiete:
ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 μM for TRPML1 .
5
5 Cited Publications
Art. -Nr.: HY-16696
CAS. Nr.: 823218-99-1
Target:
Forschungsgebiete:
SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM .
SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV) .
4
4 Cited Publications
Target:
Forschungsgebiete:
ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth .
3
3 Cited Publications
Synonyms: (-)-trans-ML-SI3
Target:
Forschungsgebiete:
(1R,2R)-ML-SI3 is an isomer of ML-SI3 and a potent inhibitor of three isoforms of TRPML. (1R,2R)-ML-SI3 inhibits TRPMLs with IC50s of 1.6 μM (TRPML1), 2.3 μM (TRPML2), and 12.5 μM (TRPML3), respectively .
2
2 Cited Publications
Target:
Forschungsgebiete:
MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study .
1
1 Cited Publications
Art. -Nr.: HY-P5381
CAS. Nr.: 329902-61-6
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
1
1 Cited Publications
Synonyms: trans-ML-SI3
Target:
Forschungsgebiete:
(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM) .
Synonyms: (+)-trans-ML-SI3
Target:
Forschungsgebiete:
(1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM) .
Art. -Nr.: HY-W008581
CAS. Nr.: 1035-77-4
Synonyms: 3-O-Methyl estradiol; 17β-Estradiol 3-methyl ether; 3-Methoxyestradiol
Forschungsgebiete:
Estradiol 3-methyl ether (EDME) is a highly selective TRPML1 ion channel antagonist and microtubule (microtubule) depolymerizing agent, with IC50 values of 0.22 μM and 3.8 μM against TRPML1 and TRPML2, respectively; it shows no activity against TRPML3. Estradiol 3-methyl ether induces the disruption of cytoplasmic microtubule networks in mammalian cells, with an EC50 of 9 μM. Independent of estrogen receptors, Estradiol 3-methyl ether blocks autophagy (autophagy), TFEB nuclear translocation, and inhibits the migration and invasion of triple-negative breast cancer cells by suppressing TRPML1. Estradiol 3-methyl ether is applicable for relevant research on triple-negative breast cancer .
Art. -Nr.: HY-169824
CAS. Nr.: 2171065-77-1
Target:
Forschungsgebiete:
TRPML modulator 1 (compound A12) is a TRPML modulator that promotes autophagy. TRPML modulator 1 AC50 in the TFEB test is less than 2 mM .
Art. -Nr.: HY-P701383
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MCOLN1 (ML4, trpml1); Mucolipin-1; MG-2; Mucolipidin; Transient receptor potential channel mucolipin 1 (trpml1)
Art. -Nr.: HY-P702374
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Mucolipin-1; MG-2; Mucolipidin; Transient receptor potential channel mucolipin 1; trpml1
Species:
Source:
Art. -Nr.: HY-108462R
CAS. Nr.: 332382-54-4
Forschungsgebiete:
ML-SA1 (Standard) is the analytical standard of ML-SA1 (HY-108462). This product is intended for research and analytical applications. ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral .
Art. -Nr.: HY-P86974
Synonyms: MCLN1_HUMAN antibody; Mcoln 1 antibody; Mcoln1 antibody; MG 2 antibody; MG-2 antibody; MG2 antibody; ML 4 antibody; ML4 antibody; MLIV antibody; MST080 antibody; MCLN1_HUMAN antibody; Mcoln 1 antibody; Mcoln1 antibody; MG 2 antibody; MG-2 antibody; MG2 antibody; ML 4 antibody; ML4 antibody; MLIV antibody; MST080 antibody; MSTP080 antibody; Mucolipidin antibody; Mucolipin 1 antibody; Mucolipin-1 antibody; Mucolipin1 antibody; TRP ML1 antibody; trpml1 antibody;
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
